Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine by Sheng Ding

Cover of: Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine | Sheng Ding

Published by Wiley-Interscience .

Written in English

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Subjects:

  • Medical genetics,
  • Biochemistry,
  • Emergency Medicine,
  • Medical / Biochemistry,
  • Medical,
  • Medical / Nursing,
  • Methodology,
  • Molecular genetics,
  • Physiological genomics,
  • Research,
  • Stem cells

Book details

The Physical Object
FormatHardcover
Number of Pages264
ID Numbers
Open LibraryOL10278555M
ISBN 100470041463
ISBN 109780470041468

Download Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine

Scientists believe that stem cells have the potential to revolutionize the treatment of numerous diseases and conditions.

This guide covers recent advances in technologies and their applications in stem cell biology, addressing the use of both embryonic and adult stem cells and discussing diverse technologies, including genome-wide expression analysis, informatics, chemical genomics.

Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine: Medicine & Health Science Books @ 5/5(1). Buy Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine: Read Kindle Store Reviews - 5/5(1).

A core reference for researchers, Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine consolidates the latest information on functional genomics and chemical biology approaches that are used to study and control the fate of stem cells. It discusses new technologies and their recent applications in various.

Download Citation | Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine | Scientists believe that stem cells Author: S. Ding. Center for Stem Cell and Regenerative Medicine, Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, San Pablo Street, Los Angeles, CAUSA Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine.

Related; Information; Close Figure by: 1. Buy Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine by Ding, Sheng online on at best prices. Fast and free shipping free returns cash on delivery available on eligible : Sheng Ding. Chemical and functional genomic approaches to stem cell biology and regenerative medicine / [edited by] Sheng Ding.

; cm. Includes bibliographical references and index. ISBN (cloth) 1. Stem cells–Research–Methodology. Physiological genomics. Molecular genetics.

Ding, Sheng, [DNLM Genomics. Stem Cells and Regenerative Medicine, Invitrogen Corporation, Carlsbad, CAUSA. Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, North Torrey Pines Road, La Jolla, CAUSA Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine.

Several regenerative medicine approaches are introduced to replace, repair, or regenerate cardiovascular tissue. Gene therapy approaches are based on either delivering exogenous genes capable of expressing therapeutic proteins or on the blockade.

Get this from a library. Chemical and functional genomic approaches to stem cell biology and regenerative medicine. [Sheng Ding;] -- Scientists believe that stem cells have the potential to repair specific tissues and to grow organs, revolutionizing the treatment of cardiovascular disease, neurodegenerative disease.

That new integrated approach is known as stem-cell biology; it is an understanding of the embryology and development together at the molecular level using engineering, imaging and cell culture principles, and it is at the heart of this seminal book. Stem Cells and Regenerative Medicine: From Molecular Embryology to Tissue Engineering is.

Xu Y, Shi Y, Ding S. A chemical approach to stem-cell biology and regenerative medicine. Nature. ; – Xu Y, Zhu X, Hahm HS, Wei W, Hao E, Hayek A, Ding S. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules.

Proceedings of the National Academy of Sciences. An improved understanding of stem-cell and regenerative biology, as well as a better control of stem-cell fate, is likely to produce treatments for many devastating diseases and injuries.

Chemical. Summary This chapter contains sections titled: Adult Stem Cells The Niche Hematopoietic Stem Cells Neural Stem Cells Epithelial Stem Cells Intestinal Stem Cells Cancer Stem Cells Summary References Adult Stem Cells - Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine - Wiley Online LibraryAuthor: Lief Fenno, Chad A.

Cowan. Stem Cell Fates: Control by Small Molecules. Wiley Encyclopedia of Chemical Biology. May 15; Julie Clark, Yue Xu, Simon Hilcove, Sheng Ding. Exploring Stem Cell Biology with Small Molecules and Functional Genomics.

Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine. Apr 11; Stem Cell Biology and Regenerative Medicine. Book Series There are 67 volumes in this series.

Published - About this series. Our understanding of stem cells has grown rapidly over the last decade. While the apparently tremendous therapeutic potential of stem cells has not yet been realized, their routine use in regeneration and. A chemical approach to stem-cell biology and regenerative medicine Yue Xu 1, Yan Shi 1 & Sheng Ding 1 An improved understanding of stem-cell and regenerative biology, as well as a better control of stem-cell fate, is likely to produce treatments for many devastating diseases and injuries.

Chemical approaches are starting. Recent work has revealed that fibroblasts are remarkably heterogeneous cells, but the appropriate lens through which to study this variation (lineage, phenotype, and plasticity) and its relevance to human biology remain unclear.

In this opinion article, we comment on recent breakthroughs in our understanding of fibroblast heterogeneity during skin wound healing, and on open questions that must. Get this from a library. Chemical and functional genomic approaches to stem cell biology and regenerative medicine. [Sheng Ding;] -- Promising technologies for exploring stem cells.

Scientists believe that stem cells have the potential to repair specific tissues and to grow organs, revolutionizing the treatment of cardiovascular. Find helpful customer reviews and review ratings for Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine at Read honest and unbiased product reviews from our users.

Journal of Stem Cell and Regenerative Biology has taken off very well as great platform and is efficiently bringing together eminent academicians, researchers, scientists, medicos and members of the general public to discuss the many ways stem cells are being used.

The field of Regenerative biology is paving way toward its major revolutionary expansion and maximum utilization in this post.

Principles of Regenerative Biology. The substrate serves as a medium for the transmission of local chemical signals, whether bound growth factors or paracrine signals secreted from nearby cells. biology and the burgeoning interest in generating or regenerating tissues or organs through various bioengineering or stem cell approaches.

For those interested in genomic approaches to studying stem cells | Explore the latest full-text research PDFs, articles, conference papers, preprints and more on STEM CELL GENOMICS.

Find methods. Functional Genomics. Functional genomics is a branch that integrates molecular biology and cell biology studies, and deals with the whole structure, function and regulation of a gene in contrast to the gene-by-gene approach of classical molecular biology technique.

From: Encyclopedia of Bioinformatics and Computational Biology, Related terms. The enzyme nicotinamide nucleotide transhydrogenase (NNT) transfers hydride from NADH to NADP + coupled to H + translocation across the inner mitochondrial membrane.

In a recent study, Kampjut and Sazanov reveal that the bifunctional NNT mechanism rules the NAD(P) + /NAD(P)H interconversion ratio, which in turn regulates antioxidant defense and sirtuin actions. Stem cells are unspecialized cells that can divide, renew, and differentiate into specialized cell types, properties that make these cells an ideal source for regenerative medicine.

Recent advances in deriving and culturing human embryonic stem cells, induced pluripotent stem cells, and adult stem cells provide important models systems to gain.

In book: Chemical Biology in Regenerative Medicine, pp One valuable regenerative medicine tool is stem cell-based therapy. A Combined Chemical and Genetic Approach. Launched with a charitable gift from the Quellos Group, the Quellos High-Throughput Screening (HTS) Core is the newest ISCRM facility.

The brainchild of Dr. Randall Moon, the HTS core was created to serve clients from both the academic and commercial worlds utilizing laboratory automation and robotics. Agu CA, Soares FAC, Alderton A, Patel M, Ansari R, Patel S, et al.

Successful generation of human induced pluripotent stem cell lines from blood samples held at. Request PDF | Chemical Biology in Regenerative Medicine: Bridging Stem Cells and Future Therapies | For many years, the process of development was.

Chemical Biology in Regenerative Medicine: Bridging Stem Cells and Future Therapies. The field of regenerative medicine has advanced at a rapid pace and this comprehensive summary of new developments is a timely contribution to the field as clinical trials have begun to assess the safety and efficacy of cell-based therapies.

Regenerative medicine, the most recent and emerging branch of medical science, deals with functional restoration of tissues or organs for the patient suffering from severe injuries or chronic disease. The spectacular progress in the field of stem cell research has laid the foundation for cell based therapies of disease which cannot be cured by conventional medicines.

Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecedented in its combination of biology with a great many other sciences, from physics to ecology, from mathematics to medicine, and from philosophy to chemistry.

Mesenchymal stem/stromal cells (MSC) show widespread application for a variety of clinical conditions; therefore, their use necessitates continuous monitoring of their safety. The risk assessment of mesenchymal stem cell-based therapies cannot be separated from an accurate and deep knowledge of their biological properties and in vitro and in vivo behavior.

It is important to note that genomic instability is not a characteristic of human stem cells only, but is a common phenomenon in mouse stem cells as well (Ben-David and Benvenisty, ; Pasi et al., ; Quinlan et al., ), and it is likely to be found in stem cell cultures of all the species used in biomedical the pluripotent field, mouse PSCs are the most studied system, and.

Chemical Biology in Regenerative Medicine: Bridging Stem Cells and Future Therapies. The field of regenerative medicine has advanced at a rapid pace and this comprehensive summary of new developments is a timely contribution to the field as clinical trials have begun to assess the safety and efficacy of cell–based therapies.

These cells have several limitations in addition to being a promising source. To overcome these limitations, stem cells which are unproblematic and posses embryonic stem cell features are generated. In this context, in this chapter induced pluripotent stem cells (ipsc) were discussed.

Chapter 3 Stem Cells in Regenerative Medicine. safety and efficacy of stem cell and regenerative medicine therapies to treat human disease. References 1. Cao F, Drukker M, Lin S, Sheikh AY, Xie X, Li Z, Connolly AJ, Weissman IL, Wu JC.

Molecular imaging of embryonic stem cell misbehavior and suicide gene ablation. Cloning and stem cells. ; 2. Sharma et al. demonstrate that human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are susceptible to SARS-CoV-2 infection.

This establishes a platform for understanding the mechanisms of cardiac-specific infection by SARS-CoV-2 in vitro and could potentially be employed to develop antiviral compounds. Figure 1. General schematic of the chemical genetic process. a, Forward chemical genetics involves the screening of synthetic molecules in cells or organisms for phenotypic changes, the selection of a molecule that induces a phenotype of interest, and the eventual identification of the protein target(s) of the small molecule.

b, Reverse chemical genetics involves the overexpression of a.Researchers, graduate students, and fellows alike will find food for thought in this insightful guide tapping into the collective knowledge of leaders in the field. Stem Cells in Ophthalmology is part of the Stem Cells in Regenerative Medicine series dedicated to discussing current challenges and future directions in stem cell research.Regenerative Medicine seeks to devise new therapies for patients with severe injuries or chronic diseases in which the body’s own responses do not suffice to restore functional tissue.

To this end, Stem cell Biology and Regenerative Medicine introduces novel methods and strategies to replace or regenerate cells, tissue or organs in order to.

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